Wild-type murine models for aging research have lifespans of several years, which results in long experimental duration and late output. Here we explore the short-lived non-inbred Titan mouse (DU6) as a mouse model to test longevity interventions. We show that Titan mice exhibit increased frailty and senescence-associated beta-galactosidase activity at an early age. Dietary intervention attenuates the frailty progression of Titan mice. Additionally, cyclic administration of the senolytic drug Navitoclax at an early age increases the lifespan and reduces senescence-associated beta-galactosidase activity. Our data suggests that Titan mice can serve as a cost-effective and timely model for longevity interventions in mammals.

用于衰老研究的野生型小鼠模型寿命长达数年，导致实验周期长、产出晚。在这里，我们探索短命非近交泰坦小鼠（DU6）作为测试长寿干预措施的小鼠模型。我们发现泰坦小鼠在幼年时就表现出脆弱性和衰老相关的β-半乳糖苷酶活性的增加。饮食干预可以减轻泰坦小鼠的衰弱进程。此外，在早期周期性服用抗衰老药物 Navitoclax 可延长寿命并降低与衰老相关的 β-半乳糖苷酶活性。我们的数据表明，泰坦小鼠可以作为哺乳动物长寿干预的具有成本效益且及时的模型。