In vitro-transcribed RNA is a promising emerging class of therapeutic, but the poor specificity of cargo RNAs so far has limited their application in cancer immunotherapy. A new study reports the delivery of a synthetic circular RNA with inline cis-acting translational elements — encoding an engineered, mitochondrion-specific oncolytic protein — that shows both therapeutic and prophylactic potential against adenocarcinoma.

中文翻译：

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溶瘤环状RNA疗法

体外转录的RNA是一类很有前景的新兴治疗方法，但迄今为止，货物RNA的特异性差限制了它们在癌症免疫治疗中的应用。一项新的研究报道了一种具有内联顺式作用翻译元件的合成环状 RNA 的传递——编码一种工程化的线粒体特异性溶瘤蛋白——显示出对腺癌的治疗和预防潜力。