Type-A aortic dissection is an acute injury involving the delamination of the aorta at the parts of the aortic media. Aldehyde crosslinker-containing glues have been used to adhere to the media of the dissected aorta before joining an artificial graft. These glues effectively adhere to the aortic media; however, they show low biocompatibility due to the release of aldehyde compounds. In this study, we report innovative adhesives based on hydrophobically modified Alaska pollock gelatin (hm-ApGltn) with different alkyl or cholesteryl (Chol) groups that adhere to the media of the dissected aorta by combining hm-ApGltns with a biocompatible crosslinker, pentaerythritol poly(ethylene glycol) ether tetrasuccinimidyl glutarate. The modification of alkyl or Chol groups contributed to enhanced adhesion strength between porcine aortic media. The adhesion strength increased with increasing modification ratios of alkyl groups from propanoyl to dodecanoyl groups and then decreased at a modification ratio of ~20 mol %. Porcine aortic media adhered using 7.5Chol-ApGltn adhesive showed stretchability even when expanded and shrunk vertically by 25% at least five times. Hm-ApGltn adhesives subcutaneously injected into the backs of mice showed no severe inflammation and were degraded during the implantation period. These results indicated that hm-ApGltn adhesives have potential applications in type-A aortic dissection.

中文翻译：

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使用疏水改性阿拉斯加鳕鱼明胶基粘合剂实现主动脉夹层的稳健主动脉中膜粘合

A型主动脉夹层是一种急性损伤，涉及主动脉中层部分的分层。在连接人工移植物之前，含有醛交联剂的胶水已被用来粘附到解剖主动脉的中膜上。这些胶水有效地粘附在主动脉中膜上；然而，由于醛类化合物的释放，它们表现出较低的生物相容性。在这项研究中，我们报告了基于疏水改性阿拉斯加狭鳕明胶（hm-ApGltn）的创新粘合剂，具有不同的烷基或胆固醇（Chol）基团，通过将 hm-ApGltn 与生物相容性交联剂季戊四醇聚相结合，粘附在解剖主动脉的中膜上。 (乙二醇)醚四琥珀酰亚胺戊二酸酯。烷基或Chol基团的修饰有助于增强猪主动脉中膜之间的粘附强度。粘合强度随着烷基从丙酰基到十二烷酰基的改性比例的增加而增加，然后在改性比例为~20 mol%时下降。使用 7.5Chol-ApGltn 粘合剂粘合的猪主动脉中膜即使在垂直方向膨胀和收缩至少 5 次 25% 时也显示出可拉伸性。皮下注射到小鼠背部的Hm-ApGltn粘合剂没有表现出严重的炎症，并且在植入期间被降解。这些结果表明 hm-ApGltn 粘合剂在 A 型主动脉夹层中具有潜在的应用。