A novel approach to melanoma diagnosis—in vivo molecular skin fluorescence imaging (mSFI)—was developed to identify premalignant changes in the form of tissue remodeling related to melanoma development in humans by imaging the proximal microenvironment of lesions. The method was tested using a fluorescent peptide (ORL-1) which binds to αvβ3 integrin, a molecule associated with invasive melanoma development. A cut off score of 7 was established, differentiating melanomas from nonmelanoma nevi with 100% sensitivity, and 95.7% specificity, while identifying dysplastic nevi with the potential for melanoma development.

中文翻译：

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分子皮肤荧光成像：评估早期黑色素瘤发展的工具

开发了一种新的黑色素瘤诊断方法——体内分子皮肤荧光成像（mSFI），通过对病变的近端微环境进行成像，识别与人类黑色素瘤发展相关的组织重塑形式的癌前变化。该方法使用荧光肽（ORL-1）进行测试，该肽与αvβ3整合素结合，αvβ3整合素是一种与侵袭性黑色素瘤发展相关的分子。确定的截止分数为 7，以 100% 的敏感性和 95.7% 的特异性区分黑色素瘤和非黑色素瘤痣，同时识别具有发展为黑色素瘤潜力的发育不良痣。