Antidepressants are high-volume pharmaceuticals that accumulate to concentrations in the μg·L⁻¹ range in surface waters. The release of peptide hormones via neurosecretory cells appears as a natural target for antidepressants. Here I review research that suggests that antidepressants indeed disrupt endocrine signalling in crustaceans, by acting on the synthesis and release of neurohormones, such as crustacean hyperglycaemic hormone, moult inhibiting hormone and pigment dispersing hormone in decapods, as well as methyl farnesoate in Daphnids. Hence, antidepressants can affect hormonal regulation of physiological functions: increase in energy metabolism and activity, lowered ecdysteroid levels, potentially disrupting moult and somatic growth, reducing colour change capacity and compromising camouflage, as well as induction of male sex determination. Several studies further suggest effects of antidepressants on crustacean reproduction, but the hormonal regulation of these effects remains elusive. All things considered, a body of evidence strongly suggests that antidepressants are endocrine disrupting compounds in crustaceans.

抗抑郁药是大容量药物，在地表水中累积浓度达到μg·L ^-1范围。通过神经分泌细胞释放肽激素似乎是抗抑郁药的天然靶点。在这里，我回顾了一些研究，这些研究表明，抗抑郁药确实通过作用于神经激素的合成和释放来扰乱甲壳类动物的内分泌信号，例如甲壳类高血糖激素、十足目动物的蜕皮抑制激素和色素分散激素，以及水蚤的法尼索酸甲酯。因此，抗抑郁药可以影响生理功能的激素调节：增加能量代谢和活动，降低蜕皮类固醇水平，可能破坏换毛和体细胞生长，降低变色能力并损害伪装，以及诱导雄性性别决定。一些研究进一步表明抗抑郁药对甲壳类动物的繁殖有影响，但这些影响的激素调节仍然难以捉摸。综合考虑，大量证据强烈表明抗抑郁药是甲壳类动物的内分泌干扰化合物。