Chronic wounds, which include venous leg ulcers, diabetic foot ulcers, and pressure ulcers, are a global health issue that affects between 1% and 2% of the developed world’s population. Chronic wound healing necessitates extensive medical intervention at costly healthcare expenses. Wound care management is mainly dependent on the discovery of new and appropriate chronic wound dressing materials, and it remains a focus of research in chronic wound care. Biocompatible metallic nanoparticle-loaded wound dressing offers a novel opportunity for effectively overcoming the inherent drawbacks of traditional wound dressing materials, particularly in overcoming nonhealing chronic wounds due to their clinical complexity, for example, wound infections, chronic irritation, and trauma, persistence of foreign body or bacterial proteins, and ischemia. In this review, we will primarily focus on the advancements in nanoparticle-based antibacterial and antioxidant wound dressing materials (e.g., hydrogels, electrospun scaffolds, sponges, and films) for the treatment of chronic wounds, which overcome the limitations of traditional dressings.

中文翻译：

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金属纳米粒子-聚合物杂化物作为慢性伤口敷料的最新应用和评估

慢性伤口，包括腿部静脉溃疡、糖尿病足溃疡和压疮，是一个全球性健康问题，影响着发达国家 1% 到 2% 的人口。慢性伤口愈合需要大量的医疗干预，且医疗费用昂贵。伤口护理管理主要依赖于新型合适的慢性伤口敷料材料的发现，并且仍然是慢性伤口护理研究的热点。生物相容性金属纳米颗粒负载伤口敷料为有效克服传统伤口敷料材料的固有缺点提供了新的机会，特别是克服由于其临床复杂性而无法愈合的慢性伤口，例如伤口感染、慢性刺激和创伤、异物持续存在等。身体或细菌蛋白质，以及缺血。在这篇综述中，我们将主要关注用于治疗慢性伤口的纳米颗粒抗菌和抗氧化伤口敷料材料（例如水凝胶、静电纺丝支架、海绵和薄膜）的进展，这些材料克服了传统敷料的局限性。