Dietary cadmium (Cd²⁺) intake is implicated in the pathogenesis of hypertension and anaemia, but there is a paucity of information on the haematological changes in hypertensive conditions. This study, therefore, aims to evaluate the effects of Cd²⁺ on blood pressure (BP) and haematological indices in the Sprague–Dawley rat model. Three cohorts (n = 10 each) of control and Cd²⁺-fed male Sprague–Dawley rats were selected. Cd²⁺-exposed rats received 2.5 or 5 mg/kg b.w. cadmium chloride via gavage thrice-weekly for eight weeks, while control animals received tap water. BP and flow were measured non-invasively from rat tails twice-weekly using a CODA machine, while weights were measured thrice-weekly. Haematological indices were assessed using the Cell-Dyn Emerald Haematology Analyzer. Data were reported as mean ± SEM, and statistically analyzed using One-Way Analysis of Variance. Bonferroni post hoc test was used for multiple comparisons. Cd²⁺-exposure induced hypertension by significantly (p < 0.05) elevating systolic, diastolic, and mean arterial BPs, pulse pressure, and heart rate (HR), and increased (p < 0.05) blood flow. Mean cell volume (MCV) and haemoglobin (MCH) were significantly (p < 0.05) reduced, and red cell distribution width (RDW) significantly (p < 0.01) increased by exposure to 5 mg/kg b.w. Cd²⁺. Haemoglobin concentration (MCHC), haematocrit, haemoglobin, red blood cell, platelet, mean platelet volume, and white blood cell counts were unaffected by Cd²⁺-exposure. Cd²⁺ induced hypertension, microcytosis, hypochromicity, and anisocytosis without anaemia, which may be precursor to microcytic anaemia and coronary artery disease. This study is important in Cd²⁺-exposed environments and warrants further investigations.

膳食镉 (Cd ²⁺ ) 摄入量与高血压和贫血的发病机制有关，但有关高血压情况下血液学变化的信息很少。因此，本研究旨在评估 Cd ²⁺对 Sprague-Dawley 大鼠模型中血压 (BP) 和血液学指标的影响。选择三组（每组 n = 10）对照大鼠和 Cd ^{2+喂养的雄性 Sprague-Dawley 大鼠。}Cd ²⁺暴露的大鼠每周三次通过管饲法接受 2.5 或 5 mg/kg 体重的氯化镉，持续八周，而对照动物则接受自来水。使用 CODA 机器每周两次对大鼠尾部进行无创测量血压和流量，每周三次测量体重。使用 Cell-Dyn Emerald 血液学分析仪评估血液学指数。数据报告为平均值±SEM，并使用单向方差分析进行统计分析。Bonferroni 事后检验用于多重比较。Cd ²⁺暴露会显着（p < 0.05）升高收缩压、舒张压和平均动脉血压、脉压和心率（HR），并增加（p < 0.05）血流量，从而诱发高血压。^{暴露于 5 mg/kg bw Cd 2+}后，平均细胞体积 (MCV) 和血红蛋白 (MCH) 显着减少 (p < 0.05)，红细胞分布宽度 (RDW) 显着增加 (p < 0.01) 。血红蛋白浓度(MCHC)、血细胞比容、血红蛋白、红细胞、血小板、平均血小板体积和白细胞计数不受Cd ²⁺暴露的影响。Cd ²⁺诱发高血压、小红细胞增多症、低色素性和红细胞大小不均，但不伴有贫血，这可能是小红细胞性贫血和冠状动脉疾病的先兆。^{这项研究在 Cd 2+}暴露环境中很重要，值得进一步研究。