To assess the health impact of inhaled aerosols, it is necessary to understand aerosol dynamics and the associated dosimetry in the human respiratory tract. Although several studies have measured or simulated the dosimetry of aerosol constituents, the respiratory tract focus areas have been limited. In particular, the aerosols generated from tobacco products are complex composites and simulating their dynamics in the respiratory tract is challenging. To assess the dosimetry of the aerosol constituents of tobacco products, we developed a revised version of the Multiple-Path Particle Dosimetry (MPPD) model, which employs (1) new geometry based on CT-scanned human respiratory tract data, (2) convective mixing in the oral cavity and deep lung, and (3) constituent partitioning between the tissue and air, and clearance. The sensitivity analysis was conducted using aerosols composed of four major constituents of electronic cigarette (EC) aerosols to investigate the parameters that have a significant impact on the results. In addition, the revised model was run with 4 and 10 constituents in ECs and conventional cigarettes (CCs), respectively. Sensitivity analysis revealed that the new modeling and the physicochemical properties of constituents had a considerable impact on the simulated aerosol concentration and dosimetry. The simulations could be carried out within 3 min even when 10 constituents of CC aerosols were analyzed simultaneously. The revised model based on MPPD is an efficient and easy-to-use tool for understanding the aerosol dynamics of CC and EC constituents and their effect on the human body.

中文翻译：

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重点关注烟草产品气溶胶动力学的多路径粒子剂量测定模型的修订

为了评估吸入气溶胶对健康的影响，有必要了解气溶胶动力学和人体呼吸道中的相关剂量测定。尽管一些研究已经测量或模拟了气溶胶成分的剂量测定，但呼吸道焦点区域仍然有限。特别是，烟草产品产生的气溶胶是复杂的复合材料，模拟它们在呼吸道中的动力学具有挑战性。为了评估烟草产品气溶胶成分的剂量测定，我们开发了多路径粒子剂量测定 (MPPD) 模型的修订版本，该模型采用 (1) 基于 CT 扫描人体呼吸道数据的新几何结构，(2) 对流在口腔和肺部深处混合，以及（3）组织和空气之间的成分分配和间隙。使用由电子烟（EC）气溶胶的四种主要成分组成的气溶胶进行敏感性分析，以研究对结果有显着影响的参数。此外，修订后的模型分别针对 EC 和传统卷烟 (CC) 中的 4 种和 10 种成分进行了运行。敏感性分析表明，新的模型和成分的物理化学性质对模拟气溶胶浓度和剂量测定有相当大的影响。即使同时分析 CC 气溶胶的 10 种成分，模拟也可以在 3 分钟内完成。基于 MPPD 的修订模型是了解 CC 和 EC 成分的气溶胶动力学及其对人体影响的高效且易于使用的工具。