Progressive cerebral infarction (PCI) is a common complication in patients with ischemic stroke that leads to poor prognosis. Blood pressure (BP) can indicate post-stroke hemodynamic changes which play a key role in the development of PCI. The authors aim to investigate the association between BP-derived hemodynamic parameters and PCI. Clinical data and BP recordings were collected from 80 patients with cerebral infarction, including 40 patients with PCI and 40 patients with non-progressive cerebral infarction (NPCI). Hemodynamic parameters were calculated from the BP recordings of the first 7 days after admission, including systolic and diastolic BP, mean arterial pressure, and pulse pressure (PP), with the mean values of each group calculated and compared between daytime and nighttime, and between different days. Hemodynamic parameters and circadian BP rhythm patterns were compared between PCI and NPCI groups using t-test or non-parametric equivalent for continuous variables, Chi-squared test or Fisher's exact test for categorical variables, Cox proportional hazards regression analysis and binary logistic regression analysis for potential risk factors. In PCI and NPCI groups, significant decrease of daytime systolic BP appeared on the second and sixth days, respectively. Systolic BP and fibrinogen at admission, daytime systolic BP of the first day, nighttime systolic BP of the third day, PP, and the ratio of abnormal BP circadian rhythms were all higher in the PCI group. PCI and NPCI groups were significantly different in BP circadian rhythm pattern. PCI is associated with higher systolic BP, PP and more abnormal circadian rhythms of BP.

中文翻译：

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进行性脑梗死的血流动力学变化：基于血压监测的观察性研究

进行性脑梗死（PCI）是缺血性脑卒中患者常见的并发症，导致预后不良。血压（BP）可以指示中风后血流动力学的变化，这在 PCI 的发展中起着关键作用。作者旨在研究 BP 衍生的血流动力学参数与 PCI 之间的关联。收集了 80 名脑梗死患者的临床数据和血压记录，其中 40 名接受 PCI 的患者和 40 名非进行性脑梗死 (NPCI) 患者。根据入院后7天的血压记录计算血流动力学参数，包括收缩压、舒张压、平均动脉压、脉压（PP），计算各组的平均值，并比较白天和夜间、夜间和夜间的血流动力学参数。不同的日子。使用t检验或非参数等效连续变量、卡方检验或 Fisher 精确检验对分类变量、Cox 比例风险回归分析和二元 Logistic 回归分析，比较 PCI 组和 NPCI 组之间的血流动力学参数和昼夜血压节律模式。潜在的风险因素。PCI 和 NPCI 组中，白天收缩压分别在第二天和第六天显着下降。PCI组入院时收缩压、纤维蛋白原、第一天白天收缩压、第三天夜间收缩压、PP、血压昼夜节律异常比例均较高。PCI组和NPCI组的血压昼夜节律模式存在显着差异。PCI 与较高的收缩压、PP 和更多异常的血压昼夜节律相关。