Targeting translational factor proteins (TFPs) presents significant promise for the development of innovative antitubercular drugs. Previous insights from antibiotic binding mechanisms and recently solved 3D crystal structures of () elongation factor thermo unstable–GDP (EF-Tu–GDP), elongation factor thermo stable–EF-Tu (EF-Ts–EF-Tu), and elongation factor G–GDP (EF-G–GDP) have opened up new avenues for the design and development of potent antituberculosis (anti-TB) therapies.

中文翻译：

---

解锁抗结核药物开发的转化机制

靶向翻译因子蛋白（TFP）为创新抗结核药物的开发带来了巨大的希望。先前对抗生素结合机制的见解和最近解决的 () 热不稳定伸长因子 –GDP (EF-Tu–GDP)、热稳定伸长因子 –EF-Tu (EF-Ts–EF-Tu) 和伸长因子的 3D 晶体结构G-GDP（EF-G-GDP）为设计和开发有效的抗结核（抗结核）疗法开辟了新途径。