The separation of proteins in biological samples plays an essential role in the development of disease detection, drug discovery, and biological analysis. Protein imprinted polymers (PIPs) serve as a tool to capture target proteins specifically and selectively from complex media for separation purposes. Whereas conventional molecularly imprinted polymer is time-consuming in terms of incubation studies and solvent removal, magnetic particles are introduced using their magnetic properties for sedimentation and separation, resulting in saving extraction and centrifugation steps. Magnetic protein imprinted polymers (MPIPs), which combine molecularly imprinting materials with magnetic properties, have emerged as a new area of research hotspot. This review provides an overview of MPIPs for proteins, including synthesis, preparation strategies, and applications. Moreover, it also looks forward to the future directions for research in this emerging field.

中文翻译：

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磁性微球上蛋白质分子印迹的最新进展

生物样品中蛋白质的分离在疾病检测、药物发现和生物分析的发展中发挥着重要作用。蛋白质印迹聚合物 (PIP) 是一种从复杂介质中特异性、选择性地捕获目标蛋白质以实现分离目的的工具。传统的分子印迹聚合物在孵化研究和溶剂去除方面非常耗时，而磁性颗粒则利用其磁性进行沉降和分离，从而节省了提取和离心步骤。磁性蛋白印迹聚合物（MPIPs）将分子印迹材料与磁性相结合，已成为一个新的研究热点。本综述概述了蛋白质的 MPIP，包括合成、制备策略和应用。此外，还展望了这一新兴领域未来的研究方向。