Objective

To investigate the correlation between different expression levels of Ki-67 and ultrasonographic features in primary breast lymphoma (PBL), in order to guide clinical prediction of malignant degree and prognosis of PBL by noninvasive ultrasonography.

Methods

The ultrasonographic characteristics of PBL proved by pathology were retrospectively summarized and analyzed, and the general clinical data, pathological types and the expression level of Ki-67 in PBL were summarized, and the correlation between the ultrasonographic characteristics and different expression levels of Ki-67 was analyzed.

Results

In this study,The main ultrasonic manifestations of PBL were as follows: the lesions were mostly located in the left breast, large size, irregular morphology, uneven echo, no burr sign, posterior echo enhancement effect, blood flow signal, parallel growth, and no calcification. All the cases had different levels of Ki-67 expression. Among them, in the high expression group (Ki-67 ≥ 80%), 3 cases had burr sign and 13 cases had clear boundary, in the low expression group (Ki-67 < 80%), 12 cases had burr sign and 4 cases had clear boundary, and the difference between the two groups was statistically significant (P < 0.05). In the rest, there was no statistically significant difference between the two groups (P > 0.05).

Conclusion

Ki-67 was expressed in PBL to varying degrees, and the ultrasound images of PBL in the high expression group mostly showed no “burr sign” and “clear boundary”; on the contrary, the ultrasound images of PBL in the low expression group often showed “burr sign” and “unclear boundary”. Therefore, the ultrasonic images could predict the expression level of Ki-67, the malignant degree of PBL and its prognosis.

中文翻译：

---

原发性乳腺淋巴瘤中Ki-67不同表达水平与超声图像特征的相关性研究

客观的

探讨Ki-67不同表达水平与原发性乳腺淋巴瘤（PBL）超声特征的相关性，以指导临床无创超声预测PBL恶性程度及预后。

方法

对经病理证实的PBL超声图像特征进行回顾性总结和分析，总结PBL的一般临床资料、病理类型及PBL中Ki-67的表达水平，并分析其超声图像特征与不同Ki-67表达水平的相关性。被分析了。

结果

本次研究中 PBL 的超声表现主要为：病灶多位于左侧乳腺、体积较大、形态不规则、回声不均、无毛刺征、后回声增强效应、血流信号、平行生长、无钙化。所有病例均有不同水平的Ki-67表达。其中，高表达组（Ki-67≥80%），3例有毛刺征，13例边界清晰；低表达组（Ki-67＜80%），12例有毛刺征，4例有毛刺征，4例有毛刺征。病例边界清楚，两组比较差异有统计学意义（P  < 0.05）。其余方面，两组比较差异均无统计学意义（P  >0.05）。

结论

Ki-67在PBL中不同程度表达，高表达组PBL超声图像大多无“毛刺征”、“边界清晰”；相反，低表达组的PBL超声图像常出现“毛刺征”、“边界不清”。因此，超声图像可以预测Ki-67的表达水平、PBL的恶性程度及其预后。