Tauopathies, a group of neurodegenerative diseases that includes Alzheimer’s disease, commonly lead to disturbances in sleep-wake patterns and circadian rhythm disorders. The circadian rhythm, a recurring 24-hour cycle governing human biological activity, is regulated by the hypothalamic suprachiasmatic nucleus (SCN) and endogenous transcriptional-translational feedback loops. Surprisingly, little attention has been given to investigating tauopathy-driven neuropathology in the SCN and the repercussions of SCN and circadian gene dysfunction in the human brain affected by tauopathies. This review aims to provide an overview of the current literature on the vulnerability of the SCN in tauopathies in humans. Emphasis is placed on elucidating the neuronal and glial changes contributing to the widespread disruption of the molecular circadian clock. Furthermore, this review identifies areas of knowledge requiring further investigation.

中文翻译：

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tau蛋白病中视交叉上核的神经元和胶质细胞脆弱性：来自人类研究和动物模型的证据

Tau蛋白病是一组神经退行性疾病，包括阿尔茨海默病，通常会导致睡眠-觉醒模式紊乱和昼夜节律紊乱。昼夜节律是控制人类生物活动的 24 小时循环周期，由下丘脑视交叉上核 (SCN) 和内源性转录翻译反馈环路调节。令人惊讶的是，很少有人关注研究 SCN 中 tau 蛋白病驱动的神经病理学以及受 tau 蛋白病影响的人脑中 SCN 和昼夜节律基因功能障碍的影响。本综述旨在概述有关人类 tau蛋白病中 SCN 脆弱性的现有文献。重点是阐明导致分子生物钟广泛破坏的神经元和胶质细胞的变化。此外，本次审查还确定了需要进一步研究的知识领域。