Abstract

Despite considerable progress in the field of anticancer agent development, there remains a demand for more efficacious and safer drugs. The utilization of current agents in cancer treatment often leads to undesirable side effects, while the emergence of drug resistance presents a significant obstacle in achieving favorable outcomes for numerous patients. Due to their remarkable biological potential, synthetic feasibility, and structural versatility, 1,2,3-triazoles have emerged as compelling building blocks in the realm of anticancer agent and pharmaceutical compound development. This review article focuses on recent advancements in the synthesis of triazole derivatives and their application as potent drug candidates for the treatment of cancer.

中文翻译：

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三唑部分作为有效的药物分子：合成方法和作为有希望的候选抗癌药物的应用（综述）

摘要

尽管抗癌剂开发领域取得了相当大的进展，但仍然需要更有效和更安全的药物。目前的药物在癌症治疗中的使用常常会导致不良副作用，而耐药性的出现对许多患者获得良好的结果构成了重大障碍。由于其卓越的生物潜力、合成可行性和结构多功能性，1,2,3-三唑已成为抗癌剂和药物化合物开发领域引人注目的组成部分。这篇综述文章重点介绍了三唑衍生物合成的最新进展及其作为治疗癌症的有效候选药物的应用。