Today, the chemistry of quaternary ammonium compounds is rapidly developing field owing, among other things, to the need to combat periodic outbreaks of various infectious diseases, which in some cases assume pandemic proportions. This review summarizes the most recent studies, published mainly over the past 10 years, devoted to advances in the synthesis of bisquaternary ammonium compounds for various purposes. The synthetic methods include monoalkyl halogenation of diamines, dialkyl halogenation of amines, methyltrifluoromethanesulfonation reactions, and anion exchange reactions.

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双季铵化合物的合成（微评）

如今，季铵化合物的化学领域正在迅速发展，原因之一是需要对抗各种传染病的周期性爆发，这些传染病在某些情况下呈现大流行的程度。本综述总结了主要在过去 10 年发表的最新研究，致力于各种用途的双季铵化合物的合成进展。合成方法包括二胺的单烷基卤化、胺的二烷基卤化、甲基三氟甲磺化反应和阴离子交换反应。