Residential wood burning has both practical and traditional values among many indigenous communities of the US Mountain West, although household biomass burning also results in emissions that are harmful to health. In a household-level three-arm placebo-controlled randomized trial, we tested the efficacy of portable filtration units and education interventions on improving pulmonary function and blood pressure measures among elder participants that use wood stoves for residential heating. A total of 143 participants were assigned to the Education (n = 49), Filter (n = 47), and Control (n = 47) arms. Blood pressure and spirometry measures were collected multiple times during a pre-intervention winter period and during a follow-up post-intervention winter period. Despite strong PM_2.5 exposure reduction results with the Filter arm (50% lower compared to Control arm), neither this intervention nor the Education intervention translated to improvements in the selected health measures among this population with a mixture of chronic conditions. Intention to treat analysis failed to demonstrate evidence that either of the intervention arms had beneficial effects on the blood pressure or the spirometry measures. Post hoc evaluation of effect modification for blood pressure and spirometry outcomes did not reveal any interaction influence on the outcomes according to sex, residential smoking, chronic disease history, and study area.

ClinicalTrials.gov: NCT02240069.

尽管家庭生物质燃烧也会产生有害健康的排放，但住宅木材燃烧在美国西部山区的许多土著社区中具有实用和传统价值。在一项家庭级三臂安慰剂对照随机试验中，我们测试了便携式过滤装置和教育干预措施对改善使用木炉为住宅供暖的老年参与者肺功能和血压测量的功效。共有 143 名参与者被分配到教育组 ( n  = 49)、过滤组 ( n  = 47) 和控制组 ( n  = 47)。在干预前的冬季和干预后的后续冬季期间多次收集血压和肺活量测量值。尽管过滤臂的 PM _2.5暴露减少效果显着（与对照组相比降低了 50%），但这种干预措施和教育干预措施都没有转化为患有慢性疾病的人群中所选健康措施的改善。治疗意向分析未能证明任何干预组对血压或肺活量测量有有益影响的证据。对血压和肺活量测定结果的效果修正的事后评估没有显示出性别、居住吸烟、慢性病史和研究区域对结果的任何相互作用影响。

ClinicalTrials.gov：NCT02240069。