This study aims to experimentally compare the efficacy of different endodontic materials (iRoot BP Plus, Biodentine, MTA, Rootdent, and Trioxide) in the treatment of pulpitis and perforations on extracted tooth specimens. Additionally, the study aims to investigate the influence of iRoot BP Plus endodontic material on the regenerative processes following pulp amputation in laboratory animals. The secondary goal is to evaluate the effect of iRoot BP Plus on the restoration process in laboratory animals after pulp removal. The study presents a micropermeability analysis of the selected biomaterials performed on a sample of 50 single-rooted apical teeth in 2022. All teeth underwent endodontic treatment. Changes in molar morphology were investigated with eight laboratory animals (rabbits, 3 months old, all males) after simulated pulp removal and subsequent treatment with the iRoot BP Plus biomaterials. iRoot BP Plus appeared to be more effective in retrograde apical root filling than other biomaterials, as evidenced by its higher sealing effect. An experiment involving animal participants revealed the presence of protective adaptive mechanisms, which manifested in the form of an inflammatory process within 6 weeks after the dental pulp was removed. The connective tissue replaced the necrosis, and new capillaries began to form intensively. These dental outcomes suggest that iRoot BP Plus enables hermetical sealing in tooth restoration with good adhesion. Thus, it may have the ability to promote more active tissue regeneration after pulp removal.

Graphical Abstract

中文翻译：

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用于治疗根穿孔的现代方法和材料：效果比较

本研究旨在通过实验比较不同牙髓材料（iRoot BP Plus、Biodentine、MTA、Rootdent 和 Trioxy）在拔除牙齿标本上治疗牙髓炎和穿孔的疗效。此外，该研究旨在调查 iRoot BP Plus 牙髓材料对实验动物牙髓截肢后再生过程的影响。第二个目标是评估 iRoot BP Plus 对实验动物去除牙髓后恢复过程的影响。该研究对 2022 年的 50 颗单根根尖牙样本进行了所选生物材料的微渗透性分析。所有牙齿均接受了牙髓治疗。在模拟牙髓去除和随后使用 iRoot BP Plus 生物材料处理后，研究了 8 只实验动物（兔子，3 个月大，均为雄性）的磨牙形态变化。iRoo​​t BP Plus 在逆行根尖充填方面似乎比其他生物材料更有效，其更高的密封效果证明了这一点。一项涉及动物参与者的实验揭示了保护性适应机制的存在，该机制在牙髓去除后 6 周内以炎症过程的形式表现出来。结缔组织取代了坏死组织，新的毛细血管开始密集形成。这些牙科结果表明，iRoot BP Plus 能够在牙齿修复体中实现气密密封，并具有良好的附着力。因此，它可能具有在牙髓去除后促进更活跃的组织再生的能力。

图形概要