Sexual dysfunction (SD) is a common, yet under-reported non-motor symptom of PD. Common sexual symptoms among male PD patients include erectile dysfunction, premature ejaculation, and decreased sexual desire. Few research papers have examined sexual dysfunction in PD, especially in YOPD male patients, and there is no Indian research study on sexual dysfunction in YOPD. In this study, we determined the frequency of sexual dysfunction in men with YOPD, and its correlation with other motor and NMS. This prospective cross-sectional study was conducted on YOPD males who presented to the Department of Neurology, NIMHANS, Bangalore, India, from May 2021 to April 2023. The diagnosis of YOPD was made based on MDS criteria for IPD 2015. Sexual functions were evaluated by ASEX, PEDT, QUIP-RS, and sex hormone assay. The patients also underwent other motor and non-motor assessments. Statistical analysis was done using SPSS version 22.0. The study was funded by the PDMD fund. This study included 62 male YOPD patients. The mean age of cases was 44.74 ± 8.54 years. The mean duration of symptoms was 8.45 ± 6.23 years. 43.5% of the cases of PD were Akinetic rigid type. By ASEX Score grading, 46.8% of the cases had erectile dysfunction and 71% of the cases of YOPD had premature ejaculation by PEDT Score grading. 9.7% of the cases had hypersexuality by QUIP-RS. Duration of YOPD was a better predictor of Erectile Dysfunction and premature ejaculation when compared with other variables. SD was related to anxiety and depression and it had a negative impact on the patient's health-related quality of life (HR-QoL). SD should be investigated and treated as an integral part of the neurological assessment in YOPD.

性功能障碍 (SD) 是一种常见但未被充分报道的 PD 非运动症状。男性PD患者常见的性症状包括勃起功能障碍、早泄和性欲减退。很少有研究论文探讨 PD 性功能障碍，尤其是 YOPD 男性患者，并且印度也没有关于 YOPD 性功能障碍的研究。在这项研究中，我们确定了 YOPD 男性性功能障碍的频率及其与其他运动和 NMS 的相关性。这项前瞻性横断面研究针对 2021 年 5 月至 2023 年 4 月在印度班加罗尔 NIMHANS 神经内科就诊的 YOPD 男性。YOPD 的诊断是根据 2015 年 IPD 的 MDS 标准进行的。评估了性功能通过 ASEX、PEDT、QUIP-RS 和性激素测定。患者还接受了其他运动和非运动评估。使用SPSS 22.0版进行统计分析。该研究由 PDMD 基金资助。这项研究包括 62 名男性 YOPD 患者。病例的平均年龄为 44.74 ± 8.54 岁。症状平均持续时间为 8.45 ± 6.23 年。43.5%的PD病例为僵硬型运动不能型。根据ASEX评分分级，46.8%的病例存在勃起功能障碍，根据PEDT评分分级，71%的YOPD病例存在早泄。QUIP-RS 检测显示 9.7% 的病例患有性欲亢进。与其他变量相比，YOPD 的持续时间是勃起功能障碍和早泄的更好预测指标。SD与焦虑和抑郁有关，并对患者的健康相关生活质量（HR-QoL）产生负面影响。SD 应作为 YOPD 神经学评估的一个组成部分进行研究和治疗。