Vibrio cholerae (V. cholerae), the etiological agent of cholera, uses cholera toxin (CT) to cause severe diarrheal disease. Cholera is still a significant cause of mortality worldwide with about half of all cholera cases and deaths occurring in children under five. Owing to the lack of cost-effective vaccination and poor vaccine efficacy in children, there is a need for alternative preventative and therapeutic strategies. Recent advances in our knowledge of the interplay between CT-induced disease and host–pathogen metabolism have opened the door for investigating how modulation of intestinal metabolism by V. cholerae during disease impacts host intestinal immunity, the gut microbiota, and pathogen–phage interactions. In this review article, we examine recent progress in our understanding of host–pathogen interactions during V. cholerae infection and discuss future work deciphering how modulation of gut metabolism during cholera intersects these processes to enable successful fecal–oral transmission of the pathogen.

霍乱弧菌（V. cholerae）是霍乱的病原体，利用霍乱毒素（CT）引起严重的腹泻病。霍乱仍然是全世界死亡的一个重要原因，约一半的霍乱病例和死亡发生在五岁以下儿童中。由于缺乏具有成本效益的疫苗接种以及儿童疫苗功效较差，因此需要替代的预防和治疗策略。我们对 CT 诱导的疾病与宿主-病原体代谢之间相互作用的了解的最新进展为研究V调节肠道代谢打开了大门。疾病期间的霍乱会影响宿主肠道免疫力、肠道微生物群和病原体与噬菌体的相互作用。在这篇综述文章中，我们研究了对V期间宿主与病原体相互作用的理解的最新进展。霍乱感染，并讨论未来的工作，破译霍乱期间肠道代谢的调节如何与这些过程相交叉，以实现病原体的成功粪口传播。