A highly efficient and environmentally friendly method for the synthesis of 2-amino-4H-chromene-3-carbonitrile (ACC) derivatives has been successfully established. This innovative, solvent-free approach involves a tandem three-component and one-pot reaction utilizing arylaldehyde, dicyanomethane, and dimedone/cyclohexane-1,3-dione, catalyzed by 2-aminopyrazine under the mortar-pestle grinding technique. Key attributes of this synthetic strategy include its simplicity, high efficiency, cost-effectiveness, absence of column chromatography, shorter reaction times (18–40 min), and consistently high yields (89%–96%). Furthermore, computational studies have been conducted against the 4RHT protein using the synthesized compounds.

中文翻译：

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2-氨基吡嗪催化三组分一锅法构建2-氨基-4H-色烯-3-甲腈的研杵研磨和分子对接研究

成功建立了一种高效、环保的2-氨基-4H-色烯-3-甲腈（ACC）衍生物的合成方法。这种创新的无溶剂方法涉及利用芳醛、二氰基甲烷和双甲酮/环己烷-1,3-二酮，在研钵杵研磨技术下由 2-氨基吡嗪催化的串联三组分一锅反应。这种合成策略的关键属性包括简单、高效、成本效益、无需柱色谱、更短的反应时间（18-40 分钟）和始终如一的高产率（89%-96%）。此外，还使用合成的化合物对 4RHT 蛋白进行了计算研究。