Implantable neural probes have been extensively utilized in the fields of neurocircuitry, systems neuroscience, and brain-computer interface. However, the long-term functionality of these devices is hampered by the formation of glial scar and astrogliosis at the surface of electrodes. In this study, we administered KDS2010, a recently developed reversible MAO-B inhibitor, to mice through ad libitum drinking in order to prevent glial scar formation and astrogliosis. The administration of KDS2010 allowed long-term recordings of neural signals with implantable devices, which remained stable over a period of 6 months and even restored diminished neural signals after probe implantation. KDS2010 effectively prevented the formation of glial scar, which consists of reactive astrocytes and activated microglia around the implant. Furthermore, it restored neural activity by disinhibiting astrocytic MAO-B dependent tonic GABA inhibition induced by astrogliosis. We suggest that the use of KDS2010 is a promising approach to prevent glial scar formation around the implant, thereby enabling long-term functionality of neural devices.

中文翻译：

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KDS2010 是一种可逆性 MAO-B 抑制剂，可通过防止神经胶质疤痕形成来延长神经探针的寿命

植入式神经探针已广泛应用于神经回路、系统神经科学和脑机接口领域。然而，这些设备的长期功能受到电极表面神经胶质疤痕和星形胶质细胞增生的形成的阻碍。在这项研究中，我们通过随意饮酒的方式给小鼠施用 KDS2010（一种最近开发的可逆 MAO-B 抑制剂），以预防神经胶质疤痕形成和星形胶质细胞增生。KDS2010的施用允许使用植入式设备长期记录神经信号，该设备在6个月内保持稳定，甚至恢复了探针植入后减弱的神经信号。KDS2010 有效防止了神经胶质疤痕的形成，该神经胶质疤痕由植入物周围的反应性星形胶质细胞和活化的小胶质细胞组成。此外，它还通过解除星形胶质细胞增生引起的星形胶质细胞 MAO-B 依赖的强直性 GABA 抑制来恢复神经活动。我们认为，使用 KDS2010 是一种很有前景的方法，可以防止植入物周围形成神经胶质疤痕，从而实现神经装置的长期功能。