Oxidative stress is an imbalance between the body’s reactive oxygen species and antioxidant defense mechanisms. Oxidative stress is involved in the development of several cardiovascular diseases, such as pulmonary hypertension, atherosclerosis, and diabetes mellitus. A growing number of studies have suggested the potential role of oxidative stress in the pathogenesis of pulmonary embolism. Biomarkers of oxidative stress in pulmonary embolism have also been explored, such as matrix metalloproteinases, asymmetric dimethylarginine, and neutrophil/lymphocyte ratio. Here, we comprehensively summarize some oxidative stress mechanisms and biomarkers in the development of acute pulmonary embolism and summarize related treatments based on antioxidant stress to explore effective treatment strategies for acute pulmonary embolism.

中文翻译：

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急性肺栓塞中的氧化应激：新兴作用和治疗意义

氧化应激是体内活性氧和抗氧化防御机制之间的不平衡。氧化应激与多种心血管疾病的发生有关，例如肺动脉高压、动脉粥样硬化和糖尿病。越来越多的研究表明氧化应激在肺栓塞发病机制中的潜在作用。肺栓塞中氧化应激的生物标志物也已被探索，例如基质金属蛋白酶、不对称二甲基精氨酸和中性粒细胞/淋巴细胞比率。在此，我们全面总结了急性肺栓塞发生发展过程中的一些氧化应激机制和生物标志物，并总结了基于抗氧化应激的相关治疗方法，以探索急性肺栓塞的有效治疗策略。