: This review covers the literature information on the chemistry of hydrazonoyl halides with different substrates to give heterocyclic compounds. From the foregoing survey, it seems this provides a useful and convenient strategy for the synthesis of numerous heterocyclic derivatives. The subject of such reactions is still ongoing and undoubtedly will provide new fused functionalized compounds of both industrial and biological interest. A literature survey revealed that a great deal of interest has been focused on the synthesis of functionalized heterocyclic compounds due to their wide range of biological activities, such as contact dermatitis, anthelmintic, antiviral, antimicrobial, herbicidal, and anti-cancer. On the other hand, hydrazonoyl halides are interesting synthons for valuable bioactive heterocyclic compounds. The reaction of hydrazonoyl halides with various types of substrates gave a huge number of different heterocyclic systems. In this review, we collected all reactions of hydrazonoyl halides with different moieties and classified them as aryl diazo of monoheterocycles, aryldiazo of 5,5-bis-heterocycles, aryldiazo of 5,6-bis-heterocycles, aryldiazo of 6,6-bis-heterocycles, aryldiazo of 5,5,6-tri-heterocycles, aryldiazo of 5,6,6-tri-heterocycles, aryldiazo of 6,6,6-tri-heterocycles, hetero annulation of bisheterocycles, hetero annulation of tri-heterocycles, hetero-annulation of tetra-heterocycles, synthesis of spiro-heterocycles, heterocyclic ring transformations, and 1,3-dipolar cycloaddition reactions catalyzed by transition metals using hydrazonoyl halides as substrates. Most reaction types have been successfully applied and used in the production of biologically active compounds. The aim of the present survey is to consider in the reader the opportunity interactions and biological activities of hydrazonoyl halides. The information of several artificial paths and varied physics-chemical factors of such heterocycles made a special consideration of chemists in different fields to yield a combinatorial library and carry out thorough efforts in the search for hydrazonoyl halides

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亚肼基卤化物的反应和生物活性

：本综述涵盖了有关使用不同底物来生成杂环化合物的亚肼酰卤化学的文献信息。从上述调查来看，这似乎为合成众多杂环衍生物提供了一种有用且方便的策略。此类反应的主题仍在进行中，并且无疑将提供具有工业和生物学意义的新型稠合功能化化合物。文献调查显示，功能化杂环化合物的合成因其广泛的生物活性而受到极大的关注，例如接触性皮炎、驱虫、抗病毒、抗菌、除草和抗癌。另一方面，腙酰卤是有价值的生物活性杂环化合物的有趣合成子。亚肼基卤化物与各种类型的底物的反应产生大量不同的杂环体系。在这篇综述中，我们收集了具有不同部分的腙酰卤的所有反应，并将它们分类为单杂环的芳基重氮、5,5-双杂环的芳基重氮、5,6-双杂环的芳基重氮、6,6-双芳基重氮。 -杂环、5,5,6-三杂环的芳基重氮、5,6,6-三杂环的芳基重氮、6,6,6-三杂环的芳基重氮、二杂环的杂环化、三杂环的杂环化、四杂环的杂环化、螺杂环的合成、杂环转化和以腙酰卤为底物的过渡金属催化的 1,3-偶极环加成反应。大多数反应类型已成功应用于生物活性化合物的生产。本调查的目的是让读者考虑亚肼基卤化物的机会相互作用和生物活性。此类杂环的几种人工路径和不同的物理化学因素的信息，使不同领域的化学家进行了专门的考虑，建立了一个组合库，并在寻找腙酰卤方面进行了深入的努力