The main goal of this work is to expand the availability of chiral columns for the analysis of agrochemicals by gas chromatography. A broader offer of chiral stationary phases would allow shifting toward enantioselective analytical techniques environmentally more friendly for those compounds. We prepared seven chiral capillary columns based on derivatives of either, β-cyclodextrin or γ-cyclodextrins dissolved at high concentrations, in two typical polysiloxanes with different polarities, demonstrating not only the significance of the chiral selector but also of the polymer solvent for achieving adequate enantioseparation of some agrochemicals. The enantiorecognition ability of each column was evaluated with 20 volatile and semivolatile agrochemicals, possessing one or two chiral centers. Besides, to elute more polar agrochemicals, as well as to enhance enantioselectivity, three derivatization procedures targeting the carboxyl and/or amine group were evaluated. The results revealed that the prepared column consisting of octakis(2,3-di-O-acetyl-6-O-tertbutyldimethylsilyl)-γ-cyclodextrin dissolved in (14%-cyanopropyl-phenyl)-86%-methyl-polysiloxane provides the broadest enantiorecognition capacity. This column allowed the enantioseparation of seventeen chiral agrochemicals, including metalaxyl, furalaxyl, and four imidazolinones, which were not enantioseparated in the remaining columns. To the best of our knowledge, glufosinate, fluorochloridone, fenarimol, furalaxyl, and four imidazolinones were enantioseparated by gas chromatography for the first time.

中文翻译：

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通过气相色谱法分离农用化学品。探索基于溶解在聚硅氧烷中的环糊精衍生物的色谱柱

这项工作的主要目标是扩大用于气相色谱分析农用化学品的手性柱的可用性。提供更广泛的手性固定相将允许转向对这些化合物更加环保的对映选择性分析技术。我们制备了七种基于高浓度溶解在两种不同极性的典型聚硅氧烷中的β-环糊精或γ-环糊精衍生物的手性毛细管柱，不仅证明了手性选择剂的重要性，而且证明了聚合物溶剂对于实现充分的手性选择的重要性。一些农用化学品的对映体分离。各柱对20种具有1个或2个手性中心的挥发性和半挥发性农药进行了对映体识别能力的评价。此外，为了洗脱更多极性的农用化学品，以及增强对映选择性，对三种针对羧基和/或胺基的衍生化程序进行了评估。结果表明，所制备的柱由溶解在(14%-氰丙基-苯基)-86%-甲基-聚硅氧烷中的八(2,3-二-O-乙酰基-6-O-叔丁基二甲基甲硅烷基)-γ-环糊精组成，提供了最广泛的对映体识别能力。该色谱柱可实现 17 种手性农用化学品的对映分离，包括甲霜灵、呋霜灵和四种咪唑啉酮，而其余色谱柱中未对映体分离这些化合物。据我们所知，首次通过气相色谱法分离了草铵膦、氟氯酮、芬那莫、呋霜灵和四种咪唑啉酮类化合物。