Introduction Children with a history of bronchopulmonary dysplasia (BPD) may be at risk of hypoxaemia at altitude, such as during air travel. We have performed preflight hypoxic challenge testing (HCT) since 2006, incorporating British Thoracic Society (BTS) guidance since 2011, to determine which children may require oxygen during air travel. Aims We aimed to compare the outcome of HCTs in children with a history of BPD who met the 2011 BTS criteria and those who did not and, in addition to this, to interrogate the data for factors that may predict the outcome of HCT in this population. Methods We performed a retrospective analysis of data from HCTs of children with a history of BPD referred 2006–2020. Cases were excluded if the patient had a respiratory comorbidity, was still on oxygen therapy, if the test was a repeat or if the clinical record was incomplete. Descriptive and univariate analysis of the data was performed, and a binary logistic regression model was fitted. Results There were 79 HCTs, of which 24/79 (30%) did not meet BTS 2011 guidelines referral criteria. The analysis showed a greater proportion of desaturation in the group that did not meet criteria: 46% vs 27% (no statistical significance). Baseline oxygen saturations were higher in those who did not require oxygen during HCT and this variable was significant when adjusted for confounders. Conclusions This study found that the current criteria for referral for preflight testing may incorrectly identify those most at risk and highlights the need for further investigation to ensure those most at risk are being assessed prior to air travel. Data are available upon reasonable request. The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.

中文翻译：

---

早产儿缺氧激发试验转诊的回顾性分析

简介 有支气管肺发育不良 (BPD) 病史的儿童可能在高海拔地区（例如在航空旅行期间）面临低氧血症的风险。自 2006 年以来，我们一直在进行飞行前低氧挑战测试 (HCT)，并自 2011 年起纳入英国胸科学会 (BTS) 的指导，以确定哪些儿童在航空旅行期间可能需要氧气。目的 我们旨在比较符合 2011 年 BTS 标准和不符合 2011 年 BTS 标准的有 BPD 病史的儿童的 HCT 结果，除此之外，还询问数据中可能预测该人群 HCT 结果的因素。方法 我们对 2006 年至 2020 年有 BPD 病史的儿童的 HCT 数据进行了回顾性分析。如果患者患有呼吸道合并症、仍在接受氧疗、重复测试或临床记录不完整，则排除病例。对数据进行描述性和单变量分析，并拟合二元逻辑回归模型。结果 共有 79 例 HCT，其中 24/79 (30%) 不符合 BTS 2011 指南转诊标准。分析显示，不符合标准的组中去饱和比例更高：46% 对比 27%（无统计学意义）。在 HCT 期间不需要吸氧的患者的基线氧饱和度较高，并且在调整混杂因素后，该变量非常显着。结论 这项研究发现，目前转介进行飞行前测试的标准可能会错误地识别高危人群，并强调需要进一步调查，以确保在航空旅行之前对高危人群进行评估。数据可根据合理要求提供。支持本研究结果的数据可根据通讯作者的要求提供。由于隐私或道德限制，这些数据不公开。