Neisseria gonorrhoeae is a bacterial pathogen that causes gonorrhoea, a sexually transmitted infection. Increasing antimicrobial resistance in N. gonorrhoeae is providing motivation to develop new treatment options. In this study, we investigated the effectiveness of the antibiotic ramoplanin as a treatment for N. gonorrhoeae infection. We tested the effectiveness of ramoplanin in vitro against 14 World Health Organization (WHO) reference strains of N. gonorrhoeae and found that it was active against all 14 strains tested. Furthermore, in a Galleria mellonella infection model of N. gonorrhoeae WHO P, we demonstrated that ramoplanin was active in vivo without any evidence of toxicity. This suggests that ramoplanin might be a new promising antibiotic treatment for gonorrhoea.

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雷莫拉宁作为淋病奈瑟菌感染的新疗法：大蜡螟的体外和体内研究

淋病奈瑟菌 是一种引起淋病（一种性传播感染）的细菌病原体。淋病奈瑟菌耐药性的增加为开发新的治疗方案提供了动力。在这项研究中，我们研究了抗生素雷莫拉宁治疗淋病奈瑟菌感染的有效性。我们在体外测试了雷莫拉宁针对 14 种世界卫生组织 (WHO)淋病奈瑟菌参考菌株的有效性，发现它对所有 14 种测试菌株均具有活性。此外，在淋病奈瑟菌WHO P 的大蜡螟感染模型，我们证明雷莫拉宁在体内具有活性，且没有任何毒性证据。这表明雷莫拉宁可能是治疗淋病的一种新的有前景的抗生素。