Druggable cavities and allosteric modulators of the cell division cycle 7 (CDC7) kinase,Journal of Enzyme inhibition and Medicinal Chemistry

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Druggable cavities and allosteric modulators of the cell division cycle 7 (CDC7) kinase
Journal of Enzyme inhibition and Medicinal Chemistry ( IF 5.6 ) Pub Date : 2024-01-11 , DOI: 10.1080/14756366.2024.2301767
Elisa Rojas-Prats ₁ , Loreto Martinez-Gonzalez _{1,

2} , Carmen Gil ₁ , David Ramírez ₃ , Ana Martinez _{1,

2}

Affiliation

Cell division cycle 7 kinase (CDC7) has been found overexpressed in many cancer cell lines being also one of the kinases involved in the nuclear protein TDP-43 phosphorylation in vivo. Thus, inhibi...

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