Engineering hydrophobicity and manufacturability for optimized biparatopic antibody–drug conjugates targeting c-MET,mAbs

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Engineering hydrophobicity and manufacturability for optimized biparatopic antibody–drug conjugates targeting c-MET
mAbs ( IF 5.3 ) Pub Date : 2024-01-12 , DOI: 10.1080/19420862.2024.2302386
Andreas Evers ₁ , Simon Krah ₁ , Deniz Demir ₁ , Ramona Gaa ₁ , Desislava Elter ₁ , Christian Schroeter ₂ , Stefan Zielonka ₁ , Nicolas Rasche ₂ , Julia Dotterweich ₃ , Christine Knuehl ₃ , Achim Doerner ₁

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Optimal combinations of paratopes assembled into a biparatopic antibody have the capacity to mediate high-grade target cross-linking on cell membranes, leading to degradation of the target, as well...

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