Abstract

Purpose of Review

Aspirin-exacerbated respiratory disease (AERD) is a syndrome of high type 2 inflammation and is known to critically involve mast cell activation. The mast cell is an important cell in the baseline inflammatory processes in the upper and lower airway by maintaining and amplifying type 2 inflammation. But it also is prominent in the hypersensitivity reaction to COX-1 inhibition which defines this condition.

Recent Findings

Recent work highlights the mast cell as a focal point in AERD pathogenesis. Using AERD as a specific model of both high type 2 asthma and chronic sinusitis, the role of mast cell activity can be better understood in other aspects of airway inflammation.

Summary

Further dissecting out the mechanism of COX-1-mediated mast cell activation in AERD will be an important next phase in our understanding of NSAID-induced hypersensitivity as well as AERD pathophysiology.

中文翻译：

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阿司匹林加剧的呼吸系统疾病中的肥大细胞

摘要

审查目的

阿司匹林急性呼吸道疾病 (AERD) 是一种高度 2 型炎症综合征，已知与肥大细胞激活密切相关。肥大细胞是上呼吸道和下呼吸道基线炎症过程中的重要细胞，可维持和放大 2 型炎症。但它在对 COX-1 抑制的超敏反应中也很突出，这定义了这种情况。

最近的发现

最近的工作强调肥大细胞是 AERD 发病机制的焦点。使用 AERD 作为高 2 型哮喘和慢性鼻窦炎的特定模型，可以更好地理解肥大细胞活性在气道炎症的其他方面的作用。

概括

进一步剖析 AERD 中 COX-1 介导的肥大细胞激活机制将是我们理解 NSAID 诱导的超敏反应以及 AERD 病理生理学的重要下一阶段。