In this work, a design strategy for synthesis of $n$-propyl propionate and ethyl propionate by reactive distillation was proposed. Combined with previous work, the content of this research is mainly divided into two parts. Firstly, conceptual design of reactive distillation for synthesis of ethyl propionate was carried out by reactive residue curve maps analysis. Secondly, the reactive distillation process for the synthesis of $n$-propyl propionate and ethyl propionate was constructed, simulated and optimized. For the synthesis of $n$-propyl propionate system, the reactive distillation-extractive distillation, the reactive distillation-pervaporation and the reactive distillation coupled with a decanter-pervaporation hybrid processes were constructed. For the synthesis of ethyl propionate system, the reactive distillation-pervaporation hybrid process was constructed. By comparing the total annual cost and carbon dioxide emissions, it is found that the reactive distillation-pervaporation hybrid process has the best economic and environmental benefits.

在这项工作中，综合的设计策略$n$提出了通过反应精馏法制备丙酸丙酯和丙酸乙酯。结合前人的工作，本研究的内容主要分为两部分。首先，通过反应残渣曲线图分析进行了丙酸乙酯反应精馏合成的概念设计。其次，反应精馏法合成$n$丙酸丙酯和丙酸乙酯的构建、模拟和优化。对于合成$n$构建了丙酸丙酯体系、反应蒸馏-萃取蒸馏、反应蒸馏-渗透蒸发以及反应蒸馏与倾析器-渗透蒸发混合工艺。针对丙酸乙酯体系的合成，构建了反应精馏-渗透蒸发混合工艺。通过比较每年总成本和二氧化碳排放量，发现反应精馏-渗透汽化混合工艺具有最佳的经济和环境效益。