The aim of this work was to explore whether real-world walking speed (RWS) would change as a consequence of 60-day bed-rest. The main hypothesis was that daily RWS would decrease after the bed-rest, with a subsequent recovery during the first days of re-ambulation. Moreover, an exploratory analysis was done in order to understand whether there is an agreement between the loss in RWS after bed-rest and the loss in the maximum oxygen uptake capacity (VO_2max), or the loss in maximal vertical jump power (JUMP) respectively. Twenty-four subjects were randomly assigned to one of three groups: a continuous artificial gravity group, an intermittent artificial gravity group, or a control group. The fitted linear mixed effects model showed a significant decrease (p < 0.001) of RWS after the 60-day bed-rest and a subsequent increase (p < 0.001) of RWS during the 14-day recovery period in the study facility. No or little agreement was found between the loss in RWS and the loss in VO_2max capacity or the loss in maximal vertical jumping power (RWS vs. VO_2max: p = 0.81, RWS vs. JUMP: p = 0.173). Decreased RWS after bed-rest, with a follow-up recovery was observed for all three groups, regardless of the training intervention. This suggests that RWS, also in these settings, was able to reflect a de-conditioning and follow-up recovery process.

这项工作的目的是探讨现实世界的步行速度 (RWS) 是否会因 60 天卧床休息而发生变化。主要假设是卧床休息后每日 RWS 会下降，随后在重新下床活动的头几天恢复。此外，还进行了探索性分析，以了解卧床休息后 RWS 的损失与最大摄氧量 (VO _2max ) 的损失或最大垂直跳跃力 (JUMP) 的损失之间是否存在一致性。分别。二十四名受试者被随机分配到三组之一：连续人工重力组、间歇性人工重力组或对照组。 拟合的线性混合效应模型显示，在研究机构中，60 天卧床休息后 RWS显着下降 ( p < 0.001)，随后 在 14 天恢复期间 RWS增加 ( p < 0.001)。RWS 损失与 VO _2max能力损失或最大垂直跳跃力损失之间没有发现或几乎没有发现一致性（RWS 与 VO _2max：p  = 0.81，RWS 与 JUMP：p  = 0.173）。无论训练干预如何，所有三组患者卧床休息后的 RWS 均有所下降，并随后恢复。这表明 RWS 在这些环境中也能够反映去调节和后续恢复过程。