Objective. To explore the impact of non-pharmacological interventions on inhaled allergen sensitization in children during the COVID-19 pandemic. Methods. The positive rate of inhaled allergens, allergens sIgE grade, and multiple sensitization rates before and during the pandemic were analyzed retrospectively in this study. Logistic regression analysis was used to compare the positive rate of allergens before and during the pandemic, using odds ratio (OR) and OR 95% CI to investigate the impact of the pandemic on allergen sensitization. Results. Positive rates of d1 (49.5% vs. 38.5%), d2 (50.2% vs. 32.2%), e2 (10.1% vs. 6.1%), e1 (6.2% vs. 1.7%), mx2 (10.1% vs. 2.7%), sycamore (7.2% vs. 2.1%), w1 (4.0% vs. 1.7%), elm (3.1% vs. 0.6%), w6 (3.0% vs. 1.7%), and u80 (1.3% vs. 0.5%) increased significantly during the COVID-19 pandemic. After adjusting gender, age, season, and other potential influencing factors, the COVID-19 pandemic was found to be a risk factor for the positive rate of d1 (OR = 1.174, 95% CI = 1.015–1.358), d2 (OR = 1.301, 95% CI = 1.093–1.549), e2 (OR = 1.499, 95% CI = 1.280–1.756), mx2 (OR = 3.959, 95% CI = 3.358–4.446), w1 (OR = 1.828, 95% CI = 1.353–2.470, w6 (OR = 1.538, 95% CI = 1.123–2.106)), and u80 (OR = 2.521, 95% CI = 1.413–4.497) (). In addition, d1 and d2 allergen sIgE grades increased during the COVID-19 pandemic (d1: χ² = 9.576, ; d2: χ² = 39.063, ). The proportion of multiple allergies was significantly higher than that before the pandemic, with a statistical significance (χ² = 1621.815, ). Conclusion. During the COVID-19 pandemic, non-pharmacological interventions increased the positive rate of both indoor and outdoor allergens in children. The sIgE grade of dust mite allergen and multiple sensitization rates were significantly higher than those before COVID-19.

中文翻译：

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COVID-19疫情对儿童吸入性过敏原致敏的影响

客观的。探讨 COVID-19 大流行期间非药物干预措施对儿童吸入过敏原致敏的影响。方法。本研究对大流行前和大流行期间的吸入性过敏原阳性率、过敏原sIgE分级以及多重致敏率进行回顾性分析。采用Logistic回归分析比较疫情前和疫情期间过敏原阳性率，利用比值比（OR）和OR 95% CI探讨疫情对过敏原致敏的影响。结果。d1（49.5% vs. 38.5%）、d2（50.2% vs. 32.2%）、e2（10.1% vs. 6.1%）、e1（6.2% vs. 1.7%）、mx2（10.1% vs. 2.7）的阳性率%)、悬铃木 (7.2% vs. 2.1%)、w1 (4.0% vs. 1.7%)、榆木 (3.1% vs. 0.6%)、w6 (3.0% vs. 1.7%) 和 u80 (1.3% vs. 1.7%) 0.5%）在 COVID-19 大流行期间显着增加。调整性别、年龄、季节等潜在影响因素后，发现COVID-19大流行是d1（OR = 1.174，95% CI = 1.015–1.358）、d2（OR = 1.301，95% CI = 1.093–1.549)，e2（OR = 1.499，95% CI = 1.280–1.756），mx2（OR = 3.959，95% CI = 3.358–4.446），w1（OR = 1.828，95% CI = 1.353–2.470、w6（OR = 1.538，95% CI = 1.123–2.106））和 u80（OR = 2.521，95% CI = 1.413–4.497）（）。此外，在 COVID-19 大流行期间，d1 和 d2 过敏原 sIgE 等级有所增加（d1：χ ²  = 9.576，; d2： χ ²  = 39.063，）。多种过敏的比例较疫情前显着升高，具有统计学意义（ χ ²  = 1621.815，）。结论。在COVID-19大流行期间，非药物干预措施增加了儿童室内和室外过敏原的阳性率。尘螨过敏原的sIgE等级和多重致敏率均显着高于COVID-19之前。