Abstract

This study presents a novel methodology for the fabrication of bioadhesives composed of poly(2-hydroxyethyl acrylate) (PHEA), which demonstrate superior mechanical properties. Hydrogels based on PHEA were effectively synthesized through a strategy that obviates the need for crosslinkers, utilizing in situ polymerization of high-concentration 2-hydroxyethyl acrylate (HEA) monomers under persistent agitation. Optimal operational conditions, such as polymerization duration and HEA monomer concentration, were screened through rheological evaluations. In addition, the introduction of glycerol to the PHEA hydrogels yielded improvements in water-retention capacity, thus resolving limitations frequently observed in conventional aqueous-based hydrogels. Tests assessing adhesive properties indicated that the PHEA hydrogels, synthesized without crosslinkers, exhibited exceptional adhesion capabilities that exceeded those of commercially available tissue sealants. This economically viable and readily scalable fabrication technique provides a compelling pathway for the creation of robust, biocompatible bioadhesives well-suited for biomedical utilization.

Graphical abstract

中文翻译：

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通过原位聚合和持续机械混合合成无交联剂的生物粘附性 PHEA 水凝胶

摘要

这项研究提出了一种制造由聚（2-羟乙基丙烯酸酯）（PHEA）组成的生物粘合剂的新方法，该生物粘合剂表现出优异的机械性能。基于 PHEA 的水凝胶是通过一种无需交联剂的策略有效合成的，利用高浓度丙烯酸 2-羟乙酯 (HEA) 单体在持续搅拌下的原位聚合。通过流变学评估筛选最佳操作条件，例如聚合持续时间和 HEA 单体浓度。此外，将甘油引入 PHEA 水凝胶可以提高保水能力，从而解决传统水基水凝胶中经常观察到的局限性。评估粘合性能的测试表明，无需交联剂合成的 PHEA 水凝胶表现出卓越的粘合能力，超过了市售的组织密封剂。这种经济上可行且易于扩展的制造技术为创建非常适合生物医学应用的坚固、生物相容性生物粘合剂提供了一条引人注目的途径。

图形概要