Recent advances in cryo-electron microscopy (Cryo-EM) have revolutionized our understanding of the complement C5a/C3a receptors that are crucial in inflammation. A recent report by has elucidated the activation, ligand binding, selectivity, and signaling bias of these receptors, thereby enhancing structure-guided drug discovery. This paves the way for more effective anti-inflammatory therapies that target these receptors with unprecedented precision.

中文翻译：

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解码过敏毒素：揭示补体受体激活和信号转导的分子机制

冷冻电子显微镜 (Cryo-EM) 的最新进展彻底改变了我们对补体 C5a/C3a 受体的理解，补体 C5a/C3a 受体在炎症中至关重要。最近的一份报告阐明了这些受体的激活、配体结合、选择性和信号偏向，从而增强了结构引导的药物发现。这为以前所未有的精度针对这些受体的更有效的抗炎疗法铺平了道路。