Alzheimer's disease (AD) constitutes a multifactorial neurodegenerative pathology characterized by cognitive deterioration, personality alterations, and behavioral shifts. The ongoing brain impairment process poses significant challenges for therapeutic interventions due to activating multiple neurotoxic pathways. Current pharmacological interventions have shown limited efficacy and are associated with significant side effects. Approaches focusing on the early interference with disease pathways, before activation of broad neurotoxic processes, could be promising to slow down symptomatic progression of the disease. Curcumin—an integral component of traditional medicine in numerous cultures worldwide—has garnered interest as a promising AD treatment. Current research indicates that curcumin may exhibit therapeutic potential in neurodegenerative pathologies, attributed to its potent anti-inflammatory and antioxidant properties. Additionally, curcumin and its derivatives have demonstrated an ability to modulate cellular pathways via epigenetic mechanisms. This article aims to raise awareness of the neuroprotective properties of curcuminoids that could provide therapeutic benefits in AD. The paper provides a comprehensive overview of the neuroprotective efficacy of curcumin against signaling pathways that could be involved in AD and summarizes recent evidence of the biological efficiency of curcumins in vivo.

中文翻译：

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姜黄素在阿尔茨海默病中的抗氧化、抗炎和表观遗传潜力

阿尔茨海默病 (AD) 是一种多因素神经退行性病理学，其特征是认知恶化、人格改变和行为转变。由于激活多种神经毒性途径，持续的脑损伤过程对治疗干预提出了重大挑战。目前的药物干预已显示出有限的功效并且与显着的副作用相关。在广泛的神经毒性过程激活之前，专注于早期干扰疾病途径的方法可能有望减缓疾病的症状进展。姜黄素是全世界多种文化中传统医学不可或缺的组成部分，作为一种有前途的 AD 治疗方法而引起了人们的兴趣。目前的研究表明，姜黄素可能在神经退行性疾病中表现出治疗潜力，这归因于其有效的抗炎和抗氧化特性。此外，姜黄素及其衍生物已证明能够通过表观遗传机制调节细胞途径。本文旨在提高人们对姜黄素类神经保护特性的认识，这些特性可以为 AD 提供治疗益处。该论文全面概述了姜黄素对可能参与 AD 的信号通路的神经保护功效，并总结了姜黄素体内生物功效的最新证据。