Small cell lung cancer (SCLC) is a highly aggressive lung cancer variant known for its elevated risk of brain metastases (BM). While earlier meta-analyses supported the use of prophylactic cranial irradiation (PCI) to reduce BM incidence and enhance overall survival, modern MRI capabilities raise questions about PCI's universal benefit for limited-stage SCLC (LS-SCLC) patients. As a response, we have created a predictive model for BM, aiming to identify low-risk individuals who may not require PCI.

中文翻译：

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未行预防性颅脑照射的有限期小细胞肺癌患者脑转移预测模型的构建

小细胞肺癌 (SCLC) 是一种高度侵袭性的肺癌变体，因其脑转移 (BM) 风险较高而闻名。虽然早期的荟萃分析支持使用预防性颅脑照射 (PCI) 来降低 BM 发生率并提高总体生存率，但现代 MRI 功能对 PCI 对局限期 SCLC (LS-SCLC) 患者的普遍益处提出了质疑。作为回应，我们创建了 BM 预测模型，旨在识别可能不需要 PCI 的低风险个体。