Acute lung injury (ALI) is a severe condition that can progress to acute respiratory distress syndrome (ARDS), with a high mortality rate. Currently, no specific and compelling drug treatment plan exists. Mesenchymal stem cells (MSCs) have shown promising results in preclinical and clinical studies as a potential treatment for ALI and other lung-related conditions due to their immunomodulatory properties and ability to regenerate various cell types. The present study focuses on analyzing the role of umbilical cord MSC (UC-MSC))-derived exosomes in reducing lipopolysaccharide-induced ALI and investigating the mechanism involved. The study demonstrates that UC-MSC-derived exosomes effectively improved the metabolic function of alveolar macrophages and promoted their shift to an anti-inflammatory phenotype, leading to a reduction in ALI. The findings also suggest that creating three-dimensional microspheres from the MSCs first can enhance the effectiveness of the exosomes. Further research is needed to fully understand the mechanism of action and optimize the therapeutic potential of MSCs and their secretome in ALI and other lung-related conditions.

中文翻译：

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脐带间充质干细胞衍生的外泌体改善肺泡巨噬细胞功能并减少脂多糖诱导的急性肺损伤

急性肺损伤（ALI）是一种严重疾病，可发展为急性呼吸窘迫综合征（ARDS），死亡率很高。目前，尚无具体且令人信服的药物治疗计划。间充质干细胞 (MSC) 由于其免疫调节特性和再生各种细胞类型的能力，在临床前和临床研究中显示出有希望的结果，作为 ALI 和其他肺部相关疾病的潜在治疗方法。本研究重点分析脐带间充质干细胞（UC-MSC）来源的外泌体在减少脂多糖诱导的急性肺损伤中的作用并研究其机制。研究表明，UC-MSC 衍生的外泌体有效改善肺泡巨噬细胞的代谢功能，促进其向抗炎表型转变，从而减少 ALI。研究结果还表明，首先从 MSC 中创建三维微球可以增强外泌体的有效性。需要进一步的研究来充分了解 MSC 及其分泌组在 ALI 和其他肺部相关疾病中的作用机制并优化其治疗潜力。