Background Mosquito-borne diseases pose a significant global public health threat, with Malaysia's Klang Valley experiencing numerous outbreaks in densely populated urban areas. Methods This study aimed to estimate the seroprevalence of anti-dengue and anti-chikungunya antibodies among urban refugees in the Klang Valley, Malaysia, and identify associated risk factors. Results High seroprevalence of anti-dengue immunoglobulin G (IgG) and IgM (60.0% [confidence interval {CI} 55.39 to 64.48] and 9.2% [CI 6.77 to 12.25], respectively) were observed among refugees >18 years of age (χ22=11.720, p=0.003), Kachin ethnicity (χ28=72.253, p<0.001), without formal education (χ21=3.856, p=0.050), homes near waste disposal sites (χ21=10.378, p=0.001) and refugees who have experienced flooding (χ21=5.460, p=0.019). Meanwhile, the overall seroprevalence of anti-chikungunya IgG and IgM was 9.7% (CI 7.15 to 12.73) and 10.8% (CI 8.09 to 13.93), respectively, with ages 12–18 years (χ22=6.075, p=0.048), Rohingya ethnicity (χ28=31.631, p<0.001) and homes close to waste disposal sites (χ21=3.912, p=0.048) being significant risk factors. Results showed a link to poor environmental living conditions, with an increase in the vector population with higher availability of breeding sites and thus exposure to dengue and chikungunya virus. Conclusions Health education among the community is the key to disease prevention, as there are no specific antiviral drugs for treatment and limited vaccine availability.

中文翻译：

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马来西亚巴生谷城市难民中登革热和基孔肯雅病毒的血清流行率

背景 蚊媒疾病对全球公共卫生构成重大威胁，马来西亚巴生谷人口稠密的城市地区多次爆发蚊媒疾病。方法 本研究旨在估计马来西亚巴生谷城市难民中抗登革热和抗基孔肯雅抗体的血清流行率，并确定相关的危险因素。结果 在 18 岁以上的难民中观察到抗登革热免疫球蛋白 G (IgG) 和 IgM 的血清阳性率较高（分别为 60.0% [置信区间 {CI} 55.39 至 64.48] 和 9.2% [CI 6.77 至 12.25]）。 χ22=11.720，p=0.003）、克钦族（χ28=72.253，p<0.001）、未受过正规教育（χ21=3.856，p=0.050）、废物处理场附近的房屋（χ21=10.378，p=0.001）和难民经历过洪水的人（χ21=5.460，p=0.019）。与此同时，罗兴亚人 12-18 岁人群中抗基孔肯雅热 IgG 和 IgM 的总体血清阳性率分别为 9.7%（CI 7.15 至 12.73）和 10.8%（CI 8.09 至 13.93）（χ22=6.075，p=0.048）。种族（χ28=31.631，p<0.001）和家庭靠近废物处理场（χ21=3.912，p=0.048）是重要的风险因素。结果显示，这与恶劣的环境生活条件有关，媒介种群数量增加，繁殖地点增多，从而暴露于登革热和基孔肯雅病毒。结论 由于尚无特效抗病毒药物且疫苗供应有限，社区健康教育是疾病预防的关键。