Abstract

Purpose

The study aims to develop an interpenetrating polymer network (IPN) hydrogel bead. This drug carrier system with a hydrophilic polymer is designed through an ionotropic gelation technique using divalent calcium ions as a crosslinking agent. The resultant polymeric composite extends the release of the short-acting oral sulfonylurea drug, glipizide.

Methods

The IPN hydrogel beads prepared with more than one polymer bring forth better mechanical strength in contrast to a single polymeric-based network hydrogel system. This hydrogel bead of hydrophilic sodium alginate (SAL), the concentration of which ranges from 1.5 to 2.0% w/w, and xanthan gum (XAG) polymer, whose concentration ranges between 0.5 and 1.0% w/w, has been prepared to control the drug release profile. An ionotropic gelation technique with the crosslinking agent, calcium chloride at 2.5–7.5% w/w concentration, was adopted to prepare the IPN hydrogel bead drug carrier.

Results

The prepared hydrogel bead was studied for viscosity analysis of prepared composite dispersion, particle size, drug entrapment, swelling functions, and in vitro drug dissolution. An increase in xanthan gum quantity levels resulted in increased viscosity of prepared composite dispersions and hence the increased mean diameter of produced IPN hydrogel beads. Increased crosslinker concentration showed a slightly smaller IPN hydrogel bead mean diameter and increased encapsulation of loaded drug to about 88 to 91% glipizide. The in vitro drug dissolution was observed to be slower with increased xanthan gum polymer and calcium ion crosslinker concentration, which extended the drug release to 14 h. Thus, this work demonstrates that the XAG and calcium ion crosslinkers play a significant role in controlling the release of the loaded drug, glipizide.

Conclusion

Based on the results obtained, it can be concluded that the prepared novel polymeric-based IPN drug carrier system has beneficially controlled the drug release of short-acting oral sulphonyl medication and acted as an extended drug release system.

中文翻译：

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互穿聚合物网络水凝胶珠作为磺酰脲药物缓释药物载体系统的配制和表征

摘要

目的

该研究旨在开发一种互穿聚合物网络（IPN）水凝胶珠。这种具有亲水性聚合物的药物载体系统是通过使用二价钙离子作为交联剂的离子型凝胶技术设计的。所得聚合物复合材料延长了短效口服磺酰脲类药物格列吡嗪的释放。

方法

与单一基于聚合物的网络水凝胶系统相比，用一种以上聚合物制备的 IPN 水凝胶珠具有更好的机械强度。这种水凝胶珠由浓度范围为 1.5 至 2.0% w/w 的亲水性海藻酸钠 (SAL) 和浓度范围为 0.5 至 1.0% w/w 的黄原胶 (XAG) 聚合物制成，用于控制药物释放曲线。采用离子交联凝胶技术，使用浓度为 2.5-7.5% w/w 的氯化钙交联剂，制备 IPN 水凝胶珠药物载体。

结果

对制备的水凝胶珠进行了制备的复合分散体的粘度分析、粒径、药物包封、溶胀功能和体外药物溶出的研究。黄原胶数量水平的增加导致制备的复合分散体的粘度增加，因此产生的IPN水凝胶珠的平均直径增加。交联剂浓度的增加显示IPN水凝胶珠的平均直径稍小并且负载药物的包封增加至约88%至91%格列吡嗪。随着黄原胶聚合物和钙离子交联剂浓度的增加，体外药物溶出速度变慢，药物释放时间延长至 14 小时。因此，这项工作表明 XAG 和钙离子交联剂在控制负载药物格列吡嗪的释放方面发挥着重要作用。

结论

基于所获得的结果，可以得出结论，所制备的新型聚合物基IPN药物载体系统有益地控制了短效口服磺酰类药物的药物释放，并充当了缓释药物系统。