Objective To compare the efficacy and safety of non-invasive high-frequency oscillatory ventilation (NHFOV) and nasal continuous positive airway pressure (NCPAP) in preterm infants. Design The study conducted a comprehensive analysis across three databases, namely EMBASE, MEDLINE and Cochrane Central, to identify randomised controlled trials comparing NHFOV and NCPAP. Statistical analysis was performed using Review Manager V.5.3 software. Main outcomes measures The primary outcomes of the study were the intubation or reintubation rate in the NHFOV and NCPAP groups. Additionally, secondary outcomes included the partial pressure of carbon dioxide levels and major complications associated with non-invasive respiratory support ventilation. Results Ten randomised controlled studies, involving 2031 preterm infants, were included in this meta-analysis. When compared with NCPAP, NHFOV demonstrated a significant reduction in the intubation or reintubation rate (p<0.01, relative risk=0.45, 95% CI 0.37 to 0.55), and there was no statistical difference in related complications. Conclusion In preterm infants, NHFOV appears to be an effective intervention for decreasing the intubation or reintubation rate compared with NCPAP, with no increase in associated complications. Trial registration number CRD42023403968. Data are available upon reasonable request. All data relevant to the study are included in the article or uploaded as supplementary information.

中文翻译：

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早产儿无创高频振荡通气 (NHFOV) 与经鼻持续气道正压通气 (NCPAP) 的比较：系统评价和荟萃分析

目的 比较无创高频振荡通气（NHFOV）与经鼻持续气道正压通气（NCPAP）对早产儿的疗效和安全性。设计 该研究对 EMBASE、MEDLINE 和 Cochrane Central 三个数据库进行了全面分析，以确定比较 NHFOV 和 NCPAP 的随机对照试验。使用Review Manager V.5.3软件进行统计分析。主要结果指标 该研究的主要结果是 NHFOV 和 NCPAP 组的插管或再插管率。此外，次要结局包括二氧化碳分压水平和与无创呼吸支持通气相关的主要并发症。结果 本荟萃分析纳入了 10 项随机对照研究，涉及 2031 名早产儿。与NCPAP相比，NHFOV的插管或再插管率显着降低（p<0.01，相对风险=0.45，95% CI 0.37至0.55），且相关并发症无统计学差异。结论 对于早产儿，与 NCPAP 相比，NHFOV 似乎是降低插管或再插管率的有效干预措施，且相关并发症没有增加。试用注册号 CRD42023403968。数据可根据合理要求提供。与研究相关的所有数据都包含在文章中或作为补充信息上传。