Imparting aromaticity to 2-pyridone derivatives by O-alkylation resulted in new competitive and non-competitive PIM-1 kinase inhibitors with caspase-activated apoptosis,Journal of Enzyme inhibition and Medicinal Chemistry

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Imparting aromaticity to 2-pyridone derivatives by O-alkylation resulted in new competitive and non-competitive PIM-1 kinase inhibitors with caspase-activated apoptosis
Journal of Enzyme inhibition and Medicinal Chemistry ( IF 5.6 ) Pub Date : 2024-01-17 , DOI: 10.1080/14756366.2024.2304044
Marwa E. Abdelaziz ₁ , Mostafa M. M. El-Miligy ₁ , Salwa M. Fahmy ₁ , Marwa M. Abu-Serie ₂ , Aly A. Hazzaa ₁ , Mona A. Mahran ₁

Affiliation

New aromatic O-alkyl pyridine derivatives were designed and synthesised as Proviral Integration Moloney (PIM)-1 kinase inhibitors. 4c and 4f showed potent in vitro anticancer activity against NFS-6...

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