Youth with a family history of bipolar disorder (BD) may be at increased risk for mood disorders and for developing side effects after antidepressant exposure. The neurobiological basis of these risks remains poorly understood. We aimed to identify biomarkers underlying risk by characterizing abnormalities in the brain connectome of symptomatic youth at familial risk for BD.

中文翻译：

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有双相情感障碍家族风险的青少年大脑网络拓扑异常：一项基于任务的功能磁共振成像连接组研究

有双相情感障碍 (BD) 家族史的青少年患情绪障碍和接触抗抑郁药物后出现副作用的风险可能会增加。这些风险的神经生物学基础仍然知之甚少。我们的目的是通过表征有双相情感障碍家族风险的有症状青少年的脑连接组异常来确定潜在风险的生物标志物。