The current study aimed to investigate the health implications of negative work-to-family spillover on cardiovascular risk biomarkers. In a large-scale cross-sectional dataset of working or self-employed midlife and older adults in the United States ( = 1179), we examined five biomarkers linked to cardiovascular risk, including high-density lipoprotein (HDL) cholesterol, low-density lipoprotein cholesterol, triglyceride, interleukin-6, and C-reactive protein. Negative work-to-family spillover, measured using a four-item self-reported questionnaire, was included into our model to study its association with these cardiovascular risk biomarkers. Our findings indicate a significant association between negative work-to-family spillover and cardiovascular risk biomarkers – higher triglycerides (β = 0.108, < .001), interleukin-6 (β = 0.065, = .026), and C-reactive protein (β = 0.067, = .022), and lower HDL cholesterol (β = −0.104, < .001). The associations on triglycerides (β = 0.094, = .001) and HDL cholesterol (β = −0.098, < .001) remained significant even after controlling numerous control variables of demographics, medication, health-status, and health-related behaviors. The findings were also consistent against slight variations in the analytic method and adjustment for multiple comparisons. The current study supports the premise that spillover of work-related tensions into family life is associated with objective physiological changes that contribute to cardiovascular risk.

中文翻译：

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中年和老年人的工作与家庭的负面溢出压力和心血管风险生物标志物升高

目前的研究旨在调查工作与家庭的负面溢出对心血管风险生物标志物的健康影响。在美国工作或自营职业的中年人和老年人 (= 1179) 的大规模横断面数据集中，我们检查了五种与心血管风险相关的生物标志物，包括高密度脂蛋白 (HDL) 胆固醇、低密度脂蛋白脂蛋白胆固醇、甘油三酯、白细胞介素 6 和 C 反应蛋白。使用四项自我报告问卷测量的工作与家庭的负溢出效应被纳入我们的模型中，以研究其与这些心血管风险生物标志物的关联。我们的研究结果表明，工作对家庭的负面溢出效应与心血管风险生物标志物之间存在显着关联——较高的甘油三酯 (β = 0.108, < .001)、白细胞介素 6 (β = 0.065, = .026) 和 C 反应蛋白 ( β = 0.067, = .022)，并降低 HDL 胆固醇 (β = -0.104, < .001)。即使在控制了人口统计、药物、健康状况和健康相关行为等众多控制变量后，甘油三酯 (β = 0.094, = .001) 和 HDL 胆固醇 (β = -0.098, < .001) 之间的关联仍然显着。对于分析方法和多重比较调整的细微变化，研究结果也是一致的。目前的研究支持这样一个前提：工作相关的紧张情绪蔓延到家庭生活与导致心血管风险的客观生理变化有关。