Atrial fibrillation (AF) stands as a prevalent and escalating cardiac arrhythmia in the United States, with obesity emerging as a prominent modifiable risk factor. This article explores the intricate relationship between obesity and AF, delving into the multifaceted pathophysiological mechanisms linking the 2 conditions. Various factors, such as autonomic dysfunction, left atrial stretch, inflammation, and hormonal imbalances, contribute to the initiation and perpetuation of AF in obese individuals. The Atrial Fibrillation Better Care pathway, emphasizing lifestyle modifications and weight loss strategies, emerges as a practical guideline for managing AF in obesity. This comprehensive review underscores the critical role of obesity as a significant modifiable risk factor for AF, urging a proactive approach to its management. Implementing the Atrial Fibrillation Better Care approach, focusing on encouraging physical activity, promoting healthy dietary habits, and raising awareness about the risks associated with obesity prove essential in preventing and mitigating the burden of AF in the obese population.

中文翻译：

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探索肥胖与心房颤动之间复杂的相互作用：机制、治疗和临床意义。

心房颤动 (AF) 在美国是一种普遍存在且不断升级的心律失常，而肥胖已成为一个突出的可改变危险因素。本文探讨了肥胖与房颤之间的复杂关系，深入研究了这两种疾病之间的多方面病理生理机制。多种因素，如自主神经功能障碍、左心房牵张、炎症和激素失衡，都会导致肥胖个体房颤的发生和持续。心房颤动更好护理途径强调改变生活方式和减肥策略，成为管理肥胖型房颤的实用指南。这项全面的综述强调了肥胖作为 AF 的一个重要的可改变危险因素的关键作用，敦促采取积极主动的方法进行管理。实施心房颤动更好的护理方法，重点鼓励身体活动，促进健康的饮食习惯，并提高对肥胖相关风险的认识，对于预防和减轻肥胖人群房颤的负担至关重要。