Genomic features of de novo metastatic prostate cancer can clarify prognosis and direct therapy. Using multi-region profiling of synchronous primary and metastatic patient tissues, we reveal the complex evolutionary histories of this lethal disease and identify strategies to better capture the genomic features of dominant metastatic populations.

中文翻译：

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为新诊断的转移性前列腺癌建立准确的基因组学

新发转移性前列腺癌的基因组特征可以阐明预后并指导治疗。利用同步原发性和转移性患者组织的多区域分析，我们揭示了这种致命疾病的复杂进化历史，并确定了更好地捕获主要转移群体的基因组特征的策略。