Controlled internal drug-releasing (CIDR) devices are commonly used for superovulation in goats. However, such devices are unavailable in some countries, including Japan. In this technical note, we aimed to explore the efficacy of an alternative superovulation protocol using progesterone tablets in goats. We employed intravaginal progesterone tablets (LUTINAS® Vaginal Tablet 100 mg) following a standard superovulation protocol. Additionally, we assessed the ovarian dynamics using 3T-magnetic resonance imaging (MRI) 1 day preceding the progesterone treatment (Day “−1”) and 3 days before the end of treatment (Days 11–13). The ovarian monitoring was successfully performed in the short tau inversion recovery T2-weighted images of MRI, and ovulation was confirmed by the disappearance of follicles on Day 13 post-administration of the tablets. Immediately after ovulation, oviduct flushing yielded a substantial number of oocytes (13.5 ± 1.8 oocytes per animal). These findings provide evidence that the administration of progesterone tablets can serve as a viable alternative for inducing. Additionally, our findings suggest that 3T-MRI is a promising alternative to conventional ultrasonography for monitoring ovarian dynamics following superovulation in experimental goats.

中文翻译：

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通过磁共振成像评估黄体酮片诱导山羊超排卵的卵巢动态

受控体内药物释放 (CIDR) 装置通常用于山羊的超排卵。然而，此类设备在包括日本在内的一些国家/地区无法使用。在本技术说明中，我们旨在探索使用黄体酮片的替代性超排卵方案对山羊的功效。我们按照标准超排卵方案使用阴道内孕酮片（LUTINAS®阴道片 100 毫克）。此外，我们在黄体酮治疗前 1 天（“-1”天）和治疗结束前 3 天（第 11-13 天）使用 3T 磁共振成像 (MRI) 评估了卵巢动态。在 MRI 短 tau 反转恢复 T2 加权图像中成功进行了卵巢监测，并通过片剂给药后第 13 天卵泡消失证实排卵。排卵后，输卵管冲洗立即产生大量卵母细胞（每只动物 13.5 ± 1.8 卵母细胞）。这些发现提供的证据表明，服用黄体酮片剂可以作为诱导的可行替代方案。此外，我们的研究结果表明，3T-MRI 是传统超声检查的一种有前途的替代方案，用于监测实验山羊超排卵后的卵巢动态。