Glioblastoma (GBM) is a highly aggressive type of primary brain cancer with a poor prognosis, and despite intensive research, survival rates have not significantly improved. Non-coding RNAs (ncRNAs) are emerging as critical regulators of GBM pathogenesis, including angiogenesis, which is essential for tumor growth and invasion. MicroRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) have been identified as regulators of angiogenesis in GBM. miRNAs such as miR-21, miR-10b, and miR-26a promote angiogenesis by targeting anti-angiogenic factors, while lncRNAs such as H19 and MALAT1 inhibit angiogenesis by regulating pro-angiogenic factors. CircRNAs, such as circSMARCA5 and circBACH2, also regulate angiogenesis through various mechanisms. Similarly, signaling pathways such as the vascular endothelial growth factor (VEGF) pathway play critical roles in angiogenesis and have been targeted for GBM therapy. However, resistance to anti-angiogenic therapies is a significant obstacle in clinical practice. Developing novel therapeutic strategies targeting ncRNAs and angiogenesis is a promising approach for GBM. Potential targets include miRNAs, lncRNAs, circRNAs, and downstream signaling pathways that regulate angiogenesis. This review highlights the critical roles of ncRNAs and angiogenesis in GBM pathogenesis and the potential for new therapeutic strategies targeting these pathways to improve the prognosis and quality of life for GBM patients.

胶质母细胞瘤（GBM）是一种高度侵袭性的原发性脑癌，预后较差，尽管进行了大量研究，但生存率并未显着提高。非编码 RNA (ncRNA) 正在成为 GBM 发病机制的关键调节因子，包括血管生成，这对于肿瘤生长和侵袭至关重要。MicroRNA (miRNA)、长链非编码 RNA (lncRNA) 和环状 RNA (circRNA) 已被确定为 GBM 血管生成的调节因子。miR-21、miR-10b 和 miR-26a 等 miRNA 通过靶向抗血管生成因子来促进血管生成，而 H19 和 MALAT1 等 lncRNA 通过调节促血管生成因子来抑制血管生成。circRNA，例如 circSMARCA5 和 circBACH2，也通过各种机制调节血管生成。同样，血管内皮生长因子 (VEGF) 通路等信号通路在血管生成中发挥着关键作用，并且已成为 GBM 治疗的目标。然而，抗血管生成疗法的耐药性是临床实践中的一个重大障碍。开发针对 ncRNA 和血管生成的新型治疗策略是 GBM 的一种有前景的方法。潜在靶点包括 miRNA、lncRNA、circRNA 和调节血管生成的下游信号通路。这篇综述强调了 ncRNA 和血管生成在 GBM 发病机制中的关键作用，以及针对这些途径的新治疗策略改善 GBM 患者预后和生活质量的潜力。