Perirhinal cortex is a brain area that has been considered crucial for the object recognition memory (ORM). However, with the use of an ORM enhancer named RGS14₄₁₄ as gain-in-function tool, we show here that frontal association cortex and not the Perirhinal cortex is essential for the ORM of objects with complex features that consisted of detailed drawing on the object surface (complex ORM). An expression of RGS14₄₁₄, in rat brain frontal association cortex, induced the formation of long-term complex ORM, whereas the expression of the same memory enhancer in Perirhinal cortex failed to produce this effect. Instead, RGS14₄₁₄ expression in Perirhinal cortex caused the formation of ORM of objects with simple features that consisted of the shape of object (simple ORM). Further, a selective elimination of frontal association cortex neurons by treatment with an immunotoxin Ox7-SAP completely abrogated the formation of complex ORM. Thus, our results suggest that frontal association cortex plays a key role in processing of a high-order recognition memory information in brain.

中文翻译：

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额叶联合皮层在大鼠复杂特征物体长期物体识别记忆中的作用

嗅周皮层是一个被认为对物体识别记忆（ORM）至关重要的大脑区域。然而，通过使用名为 RGS14 ₄₁₄的 ORM 增强器作为功能增益工具，我们在此表明​​，对于具有复杂特征的对象的 ORM 至关重要，这些对象包括对象上的详细绘图表面（复杂的 ORM）。 RGS14 ₄₁₄在大鼠大脑额叶联合皮层中的表达诱导了长期复合ORM的形成，而相同记忆增强子在鼻周皮层中的表达未能产生这种效果。相反，RGS14 ₄₁₄在鼻周皮层中的表达引起了具有由物体形状组成的简单特征的物体的ORM（简单ORM）的形成。此外，通过免疫毒素 Ox7-SAP 处理选择性消除额叶关联皮层神经元，完全消除了复杂 ORM 的形成。因此，我们的结果表明额叶关联皮层在大脑中高阶识别记忆信息的处理中起着关键作用。