Growing evidence suggests that hypertensive individuals have a greater risk of developing depression, and depression can also increase the incidence of hypertension. In the hypertensive population, the association between triglyceride glucose (TyG) index and depression remains unclear. This study aimed to assess the association between TyG index and depression in hypertensive people through the cross-sectional study of the National Health and Nutrition Examination Survey (2007–2018). To assess the relationship between TyG index and depression in hypertensive population, we conducted weighted multiple logistic regression models and used a generalized additive model to probe for nonlinear correlations. In addition, we employed a recursive algorithm to determine the inflection point and established a two-piece linear regression model. This study enrolled 5897 individuals. In the model adjusted for all covariates, the ORs (95% CI) for the relationship between TyG index and depression in hypertensive population were 1.32 (1.12–1.54). A nonlinear association was found between TyG index and depression, with an inflection point at 8.7. After the inflection point, the ORs (95% CI) were 1.44 (1.15–1.79). Only the interaction with the obese population was statistically significant. Our study highlighted a nonlinear association between TyG index and depression in American hypertensive adults.

中文翻译：

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高血压人群甘油三酯葡萄糖指数与抑郁症的相关性

越来越多的证据表明，高血压患者患抑郁症的风险更大，而抑郁症也会增加高血压的发病率。在高血压人群中，甘油三酯葡萄糖（TyG）指数与抑郁症之间的关联仍不清楚。本研究旨在通过全国健康与营养检查调查（2007-2018）的横断面研究，评估高血压人群TyG指数与抑郁症之间的关联。为了评估高血压人群 TyG 指数与抑郁症之间的关系，我们进行了加权多元逻辑回归模型，并使用广义加性模型来探讨非线性相关性。此外，我们采用递归算法来确定拐点，并建立了两部分线性回归模型。这项研究招募了 5897 人。在调整所有协变量的模型中，高血压人群 TyG 指数与抑郁症之间关系的 OR (95% CI) 为 1.32 (1.12–1.54)。TyG 指数与抑郁症之间存在非线性关联，拐点为 8.7。拐点后，OR (95% CI) 为 1.44 (1.15–1.79)。只有与肥胖人群的相互作用具有统计显着性。我们的研究强调了美国成人高血压患者 TyG 指数与抑郁症之间的非线性关联。