Microbial biofilms promote pathogenesis by disguising antigens, facilitating immune evasion, providing protection against antibiotics and other antimicrobials and, generally, fostering survival and persistence. Environmental fluxes are known to influence biofilm formation and composition, with recent data suggesting that tobacco and tobacco-derived stimuli are particularly important mediators of biofilm initiation and development in vitro and determinants of polymicrobial communities in vivo. The evidence for tobacco-augmented biofilm formation by oral bacteria, tobacco-induced oral dysbiosis, tobacco-resistance strategies, and bacterial physiology is summarized herein. A general overview is provided alongside specific insights gained through studies of the model and archetypal, anaerobic, Gram-negative oral pathobiont, Porphyromonas gingivalis.

中文翻译：

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牙龈卟啉单胞菌和其他口腔微生物促进烟草形成生物膜

微生物生物膜通过伪装抗原、促进免疫逃避、提供针对抗生素和其他抗菌剂的保护以及通常促进生存和持久性来促进发病机制。众所周知，环境通量会影响生物膜的形成和组成，最近的数据表明，烟草和烟草衍生的刺激物是体外生物膜启动和发展的特别重要的介质，也是体内多微生物群落的决定因素。本文总结了口腔细菌增强烟草生物膜形成、烟草引起的口腔生态失调、烟草抗性策略和细菌生理学的证据。提供了总体概述以及通过对模型和原型、厌氧、革兰氏阴性口腔病原体、牙龈卟啉单胞菌的研究获得的具体见解。